The traditional Eurosensors School will be organised at the conference venue on the 4th of September, 2016.

2016 general focus:
Fundamentals for Sensors in Healthcare

School-chair: Dr. Peter FURJES (MFA, Budapest)
Advisors: Prof. A. D’Amico (Uni Roma) and Prof. Pasqualina Sarro (TU Delft)

Sunday, 2016 September 4, Budapest Congress Centre, Room Bartok
Address: 1123 Budapest, Jagelló u. 1-3

Registration fee includes:
full day program of four 90 min lectures,coffee breaks and sandwich-lunch.

Early bird / standard fee: € 95; on-site fee €110.
Please note: the school registration does not allow conference participation and vice versa.

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Dr. Wouter Olthuis
Dr. Wouter Olthuis
Associate Professor
University of Twente, MESA+
Enschede, The Netherlands

Biography

Dr. Wouter Olthuis received his PhD in 1990 and is currently associate professor in the BIOS Lab-on-Chip group of the MESA+ Institute of Nanotechnology at the University of Twente, The Netherlands. He is responsible for the theme Electrochemical sensors and Sensor systems. He has been supervising many projects on both physical and (bio)chemical sensors and sensor systems for medical and environmental applications. He has co-authored over 120 papers (H=24) and 7 patents. From 2006 until 2011 he was also the Director of the Educational Programme of Electrical Engineering at the Faculty of Electrical Engineering, Mathematics and Computer Science at the UT. Currently, he is appointed officer on education in the executive committee of the IEEE Benelux section.

Electrochemical sensing and examples

In this lecture the basic theory of different operational principles of electrochemical sensors: potentiometry, amperometry and electrolyte conductivity will be treated along with the theory of ISFETs as a special member of the family of potentiometric sensors.

All operational principles will be accompanied by examples from our research group:

  • for potentiometry: potassium sensing with micro electrodes in the brain of a mouse (for migraine research) and the ISFET-based coulometric acid-base titrator.
  • for amperometry: mimicking drug metabolism on a microfabricated electrochemical cell.
  • for conductometry: microfluidic single sperm analysis.
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Dr. József Prechl
Dr. József Prechl
Director
Research and Development Laboratory,
Diagnosticum Ltd.
Budapest, Hungary

Biography

József Prechl graduated at Semmelweis University Medical School as a medical doctor, and then practiced at the Department of Internal Medicine, Semmelweis University. In 1996 he joined an EU project entitled 'Genetically engineered vaccines' at the University of Utrecht, Department of Immunology. He proceed his PhD project at Loránd Eötvös University (ELTE), Department of Immunology. He spent 7 months at University of Wisconsin-Madison, Department of Pathology and Laboratory Medicine, USA, as an invited scientist.

Currently he is the Director of Research and Development of Diagnosticum Ltd and employed by the Hungarian Academy of Sciences, as member of the Immunology Research Group at ELTE. He gives lectures and practical training courses at Loránd Eötvös University, on the topics of Innate immunity, Immuno-biotechnology, Immunopathology and Immunology. Currently he is involved in projects concerning: development of antigen arrays suitable for functional profiling of immune responses and development of microfluidics-based diagnostic devices and assays. He holds several patents regarding methods for the analysis of immunoreactivity.

Biomolecular recognition elements and their application in biosensors

The lecture will cover recent developments in recognition elements for biosensors.
Recognition elements are crucial components of biosensors responsible for the recognition and capture of target molecules. Living organisms offer a variety of natural recognition elements such as receptors, enzymes, antibodies, nucleic acids or even whole cells and viruses.
Proteins are especially well-suited for highly selective recognition of other molecules. Applying the basic principles of biological recognition, we can create synthetic molecules with novel binding specificities (artificial binding proteins, aptamers/spiegelmers, peptide nucleic acids etc.).
Advantages and limitations of classical and artificial biomolecular recognition elements will be discussed.

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Dr. Giampaolo Zuccheri
Dr. Giampaolo Zuccheri
Assistant professor
Department of Pharmacy and Biotechnology
University of Bologna, Italy

Biography

Giampaolo Zuccheri is since 2002 a permanent Staff Researcher and Adjunct Professor at the University of Bologna with the Department of Pharmacy and Biotechnology. He teaches Nanobiotechnology and Macromolecular Chemistry. He is also part of the Nano Institute of the Italian CNR (with the Center at the CNR-University of Modena: Center for Nanostructures and Biosystems at Surfaces)
In 2010 he has been a visiting professor at the EPFL, Switzerland, in 1994-1996 he was a Research Assistant at the Institute of Molecular Biology of the University of Oregon (U.S.A.). He did his Ph.D. in Chemistry at the University of Calabria in Cosenza (Italy). In 1991-1992, he was with the Lawrence Berkeley Laboratory. He took his diploma in Industrial Chemistry at the University of Bologna His research interests focus on the chemistry and biophysics of nucleic acids and proteins and their nanobiotechnological applications.

Nanotechnology for biosensors in healthcare

The lecture will show examples and guidelines on what nanotechnology is contributing to the growing area of biosensors for healthcare. Nanobiosensors could help reshaping the future of (nano)medicine towards early diagnosis of diseases or early detection of their etiological agents. Current projections call for this type of applications as the healthcare system is seeing a large increase of hospitalization costs and an ever expanding number of patients requesting high-quality treatment. With the predicted increase in the number of cases of cancer and the threat of newer hard-to-treat infective agents, early diagnosis will necessarily be the tool of choice in order to make treatments more effective and curb the exploding costs of the healthcare system.
As reported in the last years, the control of the structure of matter at the nanoscale is opening the way towards more sensitive biosensors, more specific recognition signals and smaller, denser biosensors.

The lecture will include examples and applications on themes such as:

  • Tailoring of surface properties through self-assembled monolayers and nanostructuring
  • Nanoparticles and nanoplasmonics for biosensing (and theranostics)
  • Self-assembling nanostructures for biosensing with special focus on DNA nanotechnology and nucleic acids biosensing.
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Dr. Roland Pohle
Dr. Roland Pohle
Siemens Corporate Research
Munich, Germany

Biography

Roland Pohle received his PhD degree in Physics from the Technical University in Munich, Germany in 2000. Since 1998 he is employed at the Corporate Research and Technology of Siemens AG and is mainly engaged in the development of solid state chemical sensors and their applications. His research interests range from fundamental investigations on surface chemistry of semiconducting metal oxides and other gas sensitive materials to the application of work function methods for the realization of low power gas sensing FET devices. He is author of over 40 publications and conference contributions and received the Eurosensors Fellow Award in 2011.

Sensor based breath analysis for non-invasive prevention, diagnosis, disease monitoring and care

Non invasive diagnosis and monitoring by breath analysis is a method attracting currently tremendous attention and is investigated in numerous projects from different perspectives. On the one hand, knowledge about correlations of biological processes and diseases and breath components is enhanced by extensive studies. On the other hand, the recent progress in performance and availability of sensors and detection techniques enables new opportunities for reliable detection of breath components as prerequisite for sensor based breath analysis.
The spectrum of applications ranges from single-marker based applications like asthma treatment monitoring guided by fractional exhaled nitric oxide (FeNO) to analysis of extremely complex gas mixtures for cancer detection or tuberculosis diagnosis.
In this context, several aspects of the applicability of different sensors technologies for breath analysis will be illustrated ranging from solid state devices like metal oxide sensors and gas sensitive field effect transistors to analytical approaches like tuneable laser spectroscopy and mass spectrometry.
In addition the importance of the understanding of sensing principles and appropriate data evaluation methods for reliable diagnosis and monitoring will be highlighted.